User blog comment:Kogath/Monster Hunter Frontier G6 Discussion/@comment-969093-20141218084922

Duremudira is not that big of a random encounter. There are "Tower Skills" to fight against it including ones for encountering it, resistance or something against poison (or frostbite?), attack up and defense up when fighting it.

The tower quest will gain a yellow text and the background of the paper when you select the quest will change to red. That's how you know he's coming for you.

When you reach his room he will invade the loading screen with his icon.

The fight is optional.