User blog comment:Lord Loss/Monster Hunter Theory... Blog/@comment-5043481-20121021210526/@comment-1011548-20121023175848

Just to go back to an earlier point, Deviljho are very good at killing things smaller than themselves, and very very bad at fighting anything bigger. Their main problem is complete lack of defense; their skin offers almost no protection at all compared to the thick scales of Rathalos, or plates of Lagicrus. Of course, this isn't a problem when they're hunting something they can kill quickly, like a Popo or wounded big monster, but when put against something they can't kill quickly - something giant, like Akantor or Ukanlos - Deviljho will get squashed or sliced open very quickly.

Although in fairness to Deviljho, there's basically nothing that can take on Akantor or Ukanlos. Crimson Fatalis has his meteors, but Akantor has a lethal combination of being well-armored and offensively vicious, so the meteors probably wouldn't take Akantor out quick enough. And there's nothing in the Tundra or Snowy Mountains that could really dream of fighting Ukanlos.

Maybe they could be preyed on by Raviente, if ever the two met, but that's pretty unlikely.